Spotlight on Brazil's Emerging Biotech Players

A report published last year in Nature Biotechnology points to the healthy growth of Brazilian biotechs against the backdrop of emerging players in India, China and South Africa. 

Of the main author's of the paper, Dr. Peter A. Singer,  states that "One thing is clear: when you think of biotechnology, its no longer just San Francisco, Boston, London and Tokyo. It's also Hyderabad, Shanghai, and Sao Paulo. While in the emerging economies it is still in it's adolescence, biotechnology is no longer the sole hegemony of the rich world. Biotechnology innovation is becoming globalized."

The paper covers 19 case studies of Brazilian-owned private health biotech companies and four public research groups. Unlike it's Indian and Chinese counterparts, the Brazilian case studies point to a focus to find affordable health technology for it's domestic population. While there is still no Pelé for biotech, there's several contenders.

"What you call a neglected disease, I call a business opportunity," said Fernando Kreutz, president of Porto Alegre based FK Biotecnologia. That type of optimism is what is needed to stay ahead of the investment opportunity curve. For Stateside investment firms not paying attention, firms like FK and diagnostics maker Katal Diagnostics, who makes a $25 TB test to replace the $150 version, represent real opportunities where development meets entrepreneurship and results in benefits for all both patients and investors. I don't want to play an armchair investment manager, but it's not hard to conclude that those who react to the current economic climate by circling the wagons and staying within our borders will miss out against those who choose to diversify abroad. 

The paper's press release notes some of the accomplishments of the Brazilian industry:

Notable products in the pipeline of various companies include:

• several monoclonal antibodies for cancer treatment (Recepta Biopharma, of São Paulo);
  
• a recombinant protein for treating melanoma as well as anti-hypertensive and an analgesic peptide – both isolated from snake venom (COINFAR, of São Paulo); and
  
• fetal, neonatal and adult stem cell therapies for cardiac disease, type I diabetes and neonatal hypoxia (Cryopraxis, Rio de Janeiro).

as well as some barriers to escalation:

A patent regime in desperate need of reform.

- Seven year wait period for patent processing

- Laws against IP protection of key biotech tools such as recombinant versions of proteins found in nature

- The national regulatory agency's final word on patented pharmaceutical products based on public access

Regulatory issues

- Lack of practical product development and manufacturing experience by regulators

- Long delayed in ethics approvals for clinical trials

- Complex navigation of biosafety and biodiversity rules

Human resources

- University centric academic models of research have yet to effectively transfer human resources specifically tailored to the health biotech sector

- Private enterprise are still working on ways to match career incentives systems currently found in academia and government sponsored research programs

We'll keep an eye of for the South African research paper and try to come up with a nice comparative review for our readers. 

Little Social Venture Start-Ups That Could: Day 1

Every day, up to the end of the month, we’ll profile one group that proves that global impact can come in small, energetic packages to help communities around the world.

We’ll kick things off with a veritable engine of developing world research that is igniting scientific exploration among developing world scientists: Seedings Labs.

The Cambridge social enterprise collects laboratory equipment academic and private sector research labs in the U.S., sorts, refurbishes it when necessary, and ships it to scientists who have passed the Seeding Labs selection criteria. Under the leadership of Echoing Green fellow, Nina Dudnick, the group has grown from a student-run outfit at Harvard to an independent technology transfer powerhouse.




Their mission has multiple benefits in different flavors:

• Greening Science: They are reducing the burden of having to discard surplus laboratory equipment by giving it second tour of duty in labs around the world.
  
  
• Democratizing Research: They are creating a generation of scientists that are home-grown, spurring local and unique research pathways, and opening the science education for students.
  
  
  
• Reversing the Brain Drain: It’s empowering scientists who would otherwise not go back to their countries after receiving advanced training in the West.
  
  
  
• Sustaining Discovery and the Next Great Minds Behind Them: This is not your weekend lab garage sale. By mapping their database of emerging research with a real-time inventory system, they can optimize shipments to the best candidates for cutting edge research in far corners of the earth.

How YOU can HELP!

• Back them with your checkbook. All our featured start-ups have real expenses behind their fantastic stories. Send Seedings Labs some Holiday cheer and when one of their scientists makes Nature, you’ll feel like your own private Wellcome Trust.
  
  
• Sign up to volunteer: If you want to see the operation first hand, contact Seeding Labs for volunteer opportunities. Packing boxes full of PCR machines and flow cytometers will energize the geek inside you on a Saturday morning
  
  
• Spread the Word: Do you work in a lab that has some extra lab equipment looking for a new home? Talk to your boss and show them how Seeding Labs can find a new home in an exotic location. Your corporate social responsibility committee will be the coolest kids in town.

More at Seedings Labs

Foldit: Competitive Protein Folding

Most of us are familiar with the Fold@Home project that allows millions of computers to share spare computing cycles to solve protein folding problems. If your screensaver is not set to provide Fold@Home some spare computing cycle, you are not alone.
Move aside Celtics: enter the league of Competitive Protein Folding.

The idea behind David Baker's project, called FoldIt is to employ battalions of gamers to provide what an army of CPUs can't: smarts. Algorithms are great, but they can't match the puzzle-solving abilities of a person dead set on solving a problem. Baker would know a thing or two about algorithms. His research launched the Rosetta@Home project which employed distributed computing power to solve proteins.



I like the concept because it combines the flattening power of the internet, the elegance of distributed computing, and a really cool gaming interface. Watch the video.

The OR Channel: TV dinners are never gonna look quite the same

When I was 3 or 4 year old, I ran into my grandfather's collection of 35mm projection slides of surgical procedures that he used to teach his students in medical school. I remember that the images were fascinating (at least for me) and left an indelible mark on my view of the human body: Try to understand a 3 year old who goes "eyes, nose, ears, hands, feet, liver, pancreas, vein." Fast forward a long time and instead of becoming a vascular surgeon like Pepe, I grew up to design devices that he could have used. Problem is that I am out of 35 mm projection slide discovery opportunities...so I ran into this today:



OR Live is a website offerings video streams of 600 different surgical procedures.
Each procedure comes from different institutions so you can get a good sense of how each procedures varies by physician and hospital.

Swarm Intelligence

National Geographic has an interesting article on swarm intelligence. We've covered previous attempts at open sourcing design and crowd sourcing. I remain a bit skeptical on the matter give that hard design is not like software. Nevertheless the article is superb.

"In biology, if you look at groups with large numbers, there are very few examples where you have a central agent," says Vijay Kumar, a professor of mechanical engineering at the University of Pennsylvania. "Everything is very distributed: They don't all talk to each other. They act on local information. And they're all anonymous. I don't care who moves the chair, as long as somebody moves the chair. To go from one robot to multiple robots, you need all three of those ideas."

More at National Geographic
Hat tip to Boing Boing